Mite-related bacterial antigens stimulate inflammatory cells in rosacea

Mite-related bacterial antigens stimulate inflammatory cells in rosacea.

BACKGROUND Patients with papulopustular rosacea have a higher density of Demodex folliculorum mites on their faces than normal subjects but the role, if any, of their mites in initiating inflammation is disputed. Selective antibiotics are effective in reducing the inflammatory changes of papulopustular rosacea, but their mode of action is unknown. OBJECTIVES To investigate whether a D. follic...

Histopathologic Study of Rosacea and the Role of Demodex Folliculorum

Background and Objective: Rosacea is a common and ill-defined disease and Demodex folliculorum has been reported in rosacea in a number of clinical studies. Since demodex mite is present in many healthy individuals, the mite may have a pathogenic role only when it is present in high densities. Therefore,...

Demodex Mite, Rosacea and Skin Melanoma; Coincidence or Association?

OBJECTIVE To examine the possible associations between Demodex folliculorum and a number of skin diseases. METHODS Standardized skin surface biopsy samples were obtained from the cheeks of 144 patients with histopathologically proven basal cell carcinoma (BCC, n = 27), squamous cell carcinoma (SCC, n = 28), melanoma (n = 23), discoid lupus erythematosus (DLE, n = 32), and rosacea (n = 34). Th...

Reply To: The Possible Combined Action of Different Trigger Agents in Rosacea.

2. Bunyaratavej S, Rujitharanawong C, Kasemsarn P, Boonchai W, Muanprasert C, Matthapan L, et al. Skin scrapings versus standardized skin surface biopsy to detect Demodex mites in patients with facial erythema of uncertain cause -a comparative study. Indian J Dermatol Venereol Leprol. 2016;82:519--22, http://dx.doi.org/10.4103/0378-6323.174423 3. Blakley BR, Rousseaux CG. Effect of ivermectin o...

Cellular inflammatory responses of man to bacterial endotoxin: a comparison with PPD and other bacterial antigens.